Sciatic Pregnancy – what options do you actually have during pregnancy, a time that should be joyful and exciting, when your sciatic nerve is acting up and makes you miserable? Pregnancy sciatica is actually a list of symptoms that become apparent when the sciatic nerve gets irritated. This nerve runs from your lower back, through the muscles of your buttocks and the back of the thighs down into your feet. When the nerve gets inflamed due to pressure by either a herniated disk, or a clenched muscle (as in piriformis syndrome) or a list of other conditions, shooting pains, a burning sensation, tingling or numbness in lower back, buttocks and even thighs may be the result.